LY303511
货号：
15514-1mg 基本售价：
350.0 元 规格：
1 mg
产品信息
概述| 货号 | 15514-1mg |
| 描述 | LY303511 is a close structural analog of LY294002 (Item No. 70920), a selective phosphatidylinositol 3-kinase (PI3K) inhibitor.1 LY303511, however, does not inhibit PI3K-dependent phosphorylation of Akt but instead has been shown to inhibit mTOR-dependent phosphorylation of S6K.1 It can reduce cell proliferation in human lung epithelial adenocarcinoma cells, blocking G2/M progression and inhibiting casein kinase 2 activity.1 LY303511 demonstrates tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) sensitizing activity in HeLa cells that are refractory to TRAIL-induced apoptosis.2 LY303511 is also reported to block voltage-gated potassium (Kv) channels.3 |
性能| 供应商 | Cayman |
| 应用文献 |
1.Kristof, A.S.,Pacheco-Rodriguez, G.,Schremmer, B., et al. LY303511 (2-piperazinyl-8-phenyl-4H-1-benzopyran-4-one) acts via phosphatidylinositol 3-kinase-independent pathways to inhibit cell proliferation via mammalian target of rapamycin (mTOR)- and non-mTOR-dependent mechanisms. J. Pharmacol. Exp. Ther. 314(3), 1134-1143 (2005).
2.Mellier, G.,Liu, D.,Bellot, G., et al. Small molecule sensitization to TRAIL is mediated via nuclear localization, phosphorylation and inhibition of chaperone activity of Hsp27. Cell Death Dis. 4, e890 (2013).
3.Pattnaik, B.R. and Hughes, B.A. Regulation of Kir channels in bovine retinal pigment epithelial cells by phosphatidylinositol 4,5-bisphosphate. Am. J. Physiol. Cell Physiol. 297(4), C1001-C1011 (2009).
|
| 运输条件 | Wet ice in continental US; may vary elsewhere |
| 存放说明 | 4 |
| 纯度 | ≥98% |
| 计算分子量 | 306.4 |
| 分子式 | C19H18N2O2 |
| CAS号 | 154447-38-8 |
| 稳定性 | ≥ 1 year |
声明| 本官网所有报价均为常温或者蓝冰运输价格，如有产品需要干冰运输，需另外加收干冰运输费。 |
