| 货号 | 15405-1g |
| 描述 | Amikacin is an aminoglycoside antibiotic derived from kanamycin A (Item No. 16140). Like other aminoglycosides, amikacin binds to bacterial ribosomes and disrupts translation.1 However, the specific binding sites differ between different aminoglycoside antibiotics, as do the mechanisms of resistance.1,2,3,4 Amikacin is effective against Gram-negative and Gram-positive bacteria.2 |
| 别名 | Antibiotic BB-K 8;BAY 41-6551;BB-K 8;Lukadin;Potentox; |
| 供应商 | Cayman |
| 应用文献 | |
| 1.Le Goffic, F.,Capmau, M.L.,Tangy, F., et al. Have deoxystreptamine aminoglycoside antibiotics the same binding site on bacterial ribosomes? J.Antibiot.(Tokyo) 33(8), 895-899 (1980). 2.Price, K.E.,Purisano, T.A.,DeFuria, M.D., et al. Activity of BB-K8 (amikacin) against clinical isolates resistant to one or more aminoglycoside antibiotics. Antimicrobial Agents and Chemotherapy 5(2), 143-152 (2014). 3.Georghiou, S.B.,Magana, M.,Garfein, R.S., et al. Evaluation of genetic mutations associated with Mycobacterium tuberculosis resistance to amikacin, kanamycin and capreomycin: A systematic review. PLoS One 7(3), e33275 (2012). 4.Davis, M.A.,Baker, K.N.K.,Orfe, L.H., et al. Discovery of a gene conferring multiple-aminoglycoside resistance in Escherichia coli. Antimicrobial Agents and Chemotherapy 54(6), 2666-2669 (2010). | |
| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥98% |
| 计算分子量 | 585.6 |
| 分子式 | C22H43N5O13 |
| CAS号 | 37517-28-5 |
| 稳定性 | ≥ 2 years |
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