| 货号 | 15374-5mg |
| 描述 | Taurolidine is a synthetic taurine analog with antimicrobial and anti-neoplastic actions. It displays broad bactericidal and fungicidal activity.1 Taurolidine and its metabolites mimic mannose by binding to the extracellular wall of bacteria, blocking adherence to epithelial and fibroblast cells.2 In addition to modulating immunoregulatory systems, taurolidine induces autophagy, apoptosis, and necrosis in human cancer cells.1,3,4,5 It produces cell death in malignant mesothelioma cells by oxidative stress in concert with inhibition of Akt signaling.6 |
| 供应商 | Cayman |
| 应用文献 | |
| 1.Calabresi, P.,Goulette, F.A. and Darnowski, J.W. Taurolidine: Cytotoxic and mechanistic evaluation of a novel antineoplastic agent. Cancer Research 61(18), 6816-6821 (2001). 2.Caruso, F.,Darnowski, J.W.,Opazo, C., et al. Taurolidine antiadhesive properties on interaction with E. coli; its transformation in biological environment and interaction with bacteria cell wall. PLoS One 5(1), e8927 (2010). 3.Watson, R.W.,Redmond, H.P.,McCarthy, J., et al. Taurolidine, an antilipopolysaccharide agent, has immunoregulatory properties that are mediated by the amino acid taurine. Journal of Leukocyte Biology 58(3), 299-306 (1995). 4.Chromik, A.M.,Daigeler, A.,Bulut, D., et al. Comparative analysis of cell death induction by taurolidine in different malignant human cancer cell lines. J.Exp.Clin.Cancer Res. 29, 21 (2010). 5.Stendel, R.,Biefer, H.R.,Dékány, G.M., et al. The antibacterial substance taurolidine exhibits anti-neoplastic action based on a mixed type of programmed cell death. Autophagy 5(2), 194-210 (2009). 6.Aceto, N.,Bertino, P.,Barbone, D., et al. Taurolidine and oxidative stress: A rationale for local treatment of mesothelioma. European Respiratory Journal 34(6), 1399-1407 (2009). | |
| 运输条件 | Wet ice in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥98% |
| 计算分子量 | 284.4 |
| 分子式 | C7H16N4O4S2 |
| CAS号 | 19388-87-5 |
| 稳定性 | ≥ 2 years |
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