| 货号 | 15371-1mg |
| 描述 | Butein is a plant polyphenol that is classified as a chalcone, due to the propenone linkage between the phenol groups. Like other polyphenols, butein is a potent antioxidant and affects the numerous pathways modulated by oxidant tone, including inflammation, cancer, and immune response.1,2,3 It inhibits 5-lipoxygenase, the enoyl-acyl-carrier protein reductase of P. falciparum, angiotensin-converting enzyme, and Src kinase (IC50 or Ki values of 0.01, 2.97, 0.73, and 65 μM, respectively).4,5,6,7 Butein is also a sirtuin activator, increasing trichostatin A (Item No. 89730)-insensitive deacetylase activity.8,9 |
| 别名 | 2’,3,4,4’-tetrahydroxy Chalcone; |
| 供应商 | Cayman |
| 应用文献 | |
| 1.Yadav, V.R.,Prasad, S.,Sung, B., et al. The role of chalcones in suppression of NF-κB-mediated inflammation and cancer. International Immunopharmacology 11(3), 295-309 (2011). 2.Lee, E.H.,Song, D.G.,Lee, J.Y., et al. Inhibitory effect of the compounds isolated from Rhus verniciflua on aldose reductase and advanced glycation endproducts. Biological and Pharmaceutical Bullentin 31(8), 1626-1630 (2008). 3.Gupta, S.C.,Kim, J.H.,Prasad, S., et al. Regulation of survival, proliferation, invasion, angiogenesis, and metastasis of tumor cells through modulation of inflammatory pathways by nutraceuticals. Cancer Metastasis Reviews 29(3), 405-434 (2010). 4.Sogawa, S.,Nihro, Y.,Ueda, H., et al. 3,4-Dihydroxychalcones as potent 5-lipoxygenase and cyclooxygenase inhibitors. Journal of Medicinal Chemistry 36(24), 3904-3909 (1993). 5.Sharma, S.K.,Parasuraman, P.,Kumar, G., et al. Green tea catechins potentiate triclosan binding to enoyl-ACP reductase from Plasmodium falciparum (PfENR). Journal of Medicinal Chemistry 50(4), 765-775 (2007). 6.Bonesi, M.,Loizzo, M.R.,Statti, G.A., et al. The synthesis and angiotensin converting enzyme (ACE) inhibitory activity of chalcones and their pyrazole derivatives. Bioorganic & Medicinal Chemistry Letters 20(6), 1990-1993 (2010). 7.McArdle, B.M.,Campitelli, M.R. and Quinn, R.J. A common protein fold topology shared by flavonoid biosynthetic enzymes and therapeutic targets. Journal of Natural Products 69(1), 14-17 (2006). 8.Wood, J.G.,Rogina, B.,Lavu, S., et al. Sirtuin activators mimic caloric restriction and delay ageing in metazoans. Nature 430, 686-689 (2004). 9.Szczepankiewicz, B.G. and Ng, P.Y. Sirtuin modulators: Targets for metabolic diseases and beyond. Current Topics in Medicinal Chemistry 8(17), 1533-1544 (2008). | |
| 运输条件 | Wet ice in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥95% |
| 计算分子量 | 272.3 |
| 分子式 | C15H12O5 |
| CAS号 | 487-52-5 |
| 稳定性 | ≥ 2 years |
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