YZ9
货号：
15352-5mg 基本售价：
350.0 元 规格：
5 mg
产品信息
概述| 货号 | 15352-5mg |
| 描述 | Cells that are rapidly proliferating or hypoxic emphasize glycolysis over oxidative phosphorylation to meet energy needs.1,2 During glycolysis, fructose 6-phosphate (F6P) is phosphorylated by 6-phosphofructo-2-kinases (PFKs) to generate fructose 2,6-bisphosphate. As PFK family members also mediate the reverse reaction as fructose 2,6-bisphosphatases, these enzymes are known as PFKFB family members. Notably, PFKFB3 is overexpressed in a wide variety of cancer cell lines.3 YZ9 is a potent inhibitor of PFKFB3, with an IC50 value of 183 nM in vitro.3 It avidly competes with F6P at PFKFB3 (Ki = 94 nM).3 YZ9 is also cell permeable, inhibiting the growth of HeLa cells with a GI50 value of 2.7 µM.3 |
| 别名 | 7-hydroxycoumarin-3-Carboxylic Acid ethyl ester; |
性能| 供应商 | Cayman |
| 应用文献 |
1.Vander Heiden, M.G.,Cantley, L.C. and Thompson, C.B. Understanding the Warburg effect: The metabolic requirements of cell proliferation. Science 324, 1029-1033 (2009).
2.Palsson-McDermott, E.M. and ONeill, L.A. The Warburg effect then and now: From cancer to inflammatory diseases. BioEssays 35(11), 965-973 (2013).
3.Seo, M.,Kim, J.D.,Neau, D., et al. Structure-based development of small molecule PFKFB3 inhibitors: A framework for potential cancer therapeutic agents targeting the Warburg effect. PLoS One 6(9), 1-12 (2011).
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| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥98% |
| 计算分子量 | 234.2 |
| 分子式 | C12H10O5 |
| CAS号 | 6093-71-6 |
| 稳定性 | ≥ 2 years |
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