CRT0066101 (hydrochloride)
货号：
15337-1mg 基本售价：
350.0 元 规格：
1 mg
产品信息
概述| 货号 | 15337-1mg |
| 描述 | Protein kinase D (PKD) is a serine/threonine protein kinase that is activated by diacylglycerol, commonly downstream of PKC signaling. The three human PKD isoforms target a variety of proteins to alter cell proliferation, survival, invasion, and protein transport. CRT0066101 is an inhibitor of all three PKD isoforms (IC50s = 1, 2.5, and 2 nM for PKD1, PKD2, and PKD3, respectively).1 It exhibits selectivity for PKD against a panel of >90 protein kinases, including PKCα, PKBα, MEK, ERK, c-Raf, c-Src, and c-Abl.1 It can block cell proliferation, induce apoptosis, and reduce the viability of pancreatic cancer cells both in vitroandin vivo.1 |
性能| 供应商 | Cayman |
| 应用文献 |
1.Harikumar, K.B.,Kunnumakkara, A.B.,Ochi, N., et al. A novel small-molecule inhibitor of protein kinase D blocks pancreatic cancer growth in vitro and in vivo. Molecular Cancer Therapeutics 9(5), 1136-1146 (2010).
|
| 运输条件 | Wet ice in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥95% |
| 计算分子量 | 447.8 |
| 分子式 | C18H22N6O • 3HCl |
| CAS号 | 1290629-45-6 |
| 稳定性 | ≥ 2 years |
声明| 本官网所有报价均为常温或者蓝冰运输价格，如有产品需要干冰运输，需另外加收干冰运输费。 |
