| 货号 | 15325-1mg |
| 描述 | STO-609 is a cell-permeable inhibitor of calcium/calmodulin-dependent kinase kinases (CaMKK) isoforms CaMKKα and CaMKKβ (Ki = 80 and 15 ng/ml, respectively).1 It also blocks autophosphorylation of both isoforms.1 STO-609 less potently inhibits CaMKII (IC50 = 10 μg/ml) and is minimally effective against several related kinases.1 It is bound, in CaMKKβ, in the ATP-binding pocket found in the kinase domain.2 STO-609 is used to evaluate the action of CaMKK isoforms both in vitro and in cells.3,4,5 |
| 供应商 | Cayman |
| 应用文献 | |
| 1.Tokumitsu, H.,Inuzuka, H.,Ishikawa, Y., et al. STO-609, a specific inhibitor of Ca2+/calmodulin-dependent protein kinase kinase. J.Bio.Chem. 278(13), 10908-10913 (2013). 2.Kukimoto-Niino, M.,Yoshikawa, S.,Takagi, T., et al. Crystal structure of the Ca2+/calmodulin-dependent protein kinase kinase in complex with the inhibitor STO-609. The Journal of Biological Chemisty 286(25), 22570-22579 (2011). 3.Yurimoto, S.,Fujimoto, T.,Magari, M., et al. In vitro substrate phosphorylation by Ca2+/calmodulin-dependent protein kinase kinase using guanosine-5-triphosphate as a phosphate donor. BMC Biochemistry 13, 27 (2012). 4.Saito, A.,Miyajima, K.,Akatsuka, J., et al. CaMKIIβ-mediated LIM-kinase activation plays a crucial role in BDNF-induced neuritogenesis. Genes to Cells 18(7), 533-543 (2013). 5.Iseli, T.J.,Turner, N.,Zeng, X.Y., et al. Activation of AMPK by bitter melon triterpenoids involves CaMKKβ. PLoS One 8(4), e62309 (2013). | |
| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥98% |
| 计算分子量 | 374.4 |
| 分子式 | C19H10N2O3 • C2H4O2 |
| CAS号 | 1173022-21-3 |
| 稳定性 | ≥ 2 years |
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