| 货号 | 15303-50g |
| 描述 | Disulfiram is a copper and zinc chelator and an irreversible inhibitor of aldehyde dehydrogenase (IC50 = 0.1 mM) that has been indicated for the treatment of alcohol dependence.1 It also inhibits the copper-dependent enzyme dopamine β-hydroxylase, which prevents the breakdown of dopamine and has been considered as a treatment for cocaine dependence.2 When in complex with copper, disulfiram has been shown to inhibit purified 20S proteasome (IC50 = 7.5 μM) and 26S proteasome (IC50 = 20 μM) from MDA-MB-0231 breast cancer cells.3,4 Because disulfiram targets the ubiquitin-proteasome pathway, it has been investigated as an anti-cancer agent. Furthermore, at 250 nM it has been shown to induce reactive oxygen species, to activate JNK and p38 pathways, and to inhibit NF-κB activity, which suppresses self-renewal in cancer stem cells.5,6 |
| 别名 | NSC 25953;Tetraethylthiuram disulfide; |
| 供应商 | Cayman |
| 应用文献 | |
| 1.Kraemer, R.J. and Deitrich, R.A. Isolation and characterization of human liver aldehyde dehydrogenase. The Journal of Biological Chemisty 243(24), 6402-6408 (1968). 2.Haile, C.N.,De La Garza, R., II,Mahoney, J.J., III, et al. The impact of disulfiram treatment on the reinforcing effects of cocaine: A randomized clinical trial. PLoS One 7(11), e47702 (2012). 3.Chen, D.,Cui, Q.C.,Yang, H., et al. Disulfiram, a clinically used anti-alcoholism drug and copper-binding agent, induces apoptotic cell death in breast cancer cultures and xenografts via inhibition of the proteasome activity. Cancer Research 66(21), 10425-10433 (2006). 4.Schmitt, S.M.,Frezza, M. and Dou, Q.P. New applications of old metal-binding drugs in the treatment of human cancer. Front.Biosci.(Schol.Ed.) 4, 375-391 (2012). 5.Liu, P.,Brown, S.,Goktug, T., et al. Cytotoxic effect of disulfiram/copper on human glioblastoma cell lines and ALDH-positive cancer-stem-like cells. Br.J.Cancer. 107(9), 1488-1497 (2012). 6.Chiba, T.,Suzuki, E.,Yuki, K., et al. Disulfiram eradicates tumor-initiating hepatocellular carcinoma cells in ROS-p38 MAPK pathway-dependent and -independent manners. PLoS One 9(1), e84807 (2014). | |
| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | 22 |
| 纯度 | ≥95% |
| 计算分子量 | 296.5 |
| 分子式 | C10H20N2S4 |
| CAS号 | 97-77-8 |
| 稳定性 | ≥ 2 years |
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