| 货号 | 15278-50mg |
| 描述 | Clotrimazole is an imidazole antifungal that is active against a wide variety of fungal forms and is effective in many types of fungal infections.1,2,3,4 It tightly binds sterol 14-α demethylase isoform B from A. fumigatus(KD = 103 nM) and, like other imidazoles, disturbs the fungal cell membrane.5,4 In mammalian cells, clotrimazole potently inhibits the calcium-dependent potassium channels Kv1.3 and IK-1 (IC50 = 6.0 and 0.07 µM, respectively).6 |
| 别名 | BAY-B-5087;Canesten;NSC 257473; |
| 供应商 | Cayman |
| 应用文献 | |
| 1.Burgess, M.A. and Bodey, G.P. Clotrimazole (Bay b 5097): In vitro and clinical pharmacological studies. Antimicrobial Agents and Chemotherapy 2(6), 423-426 (1972). 2.Shadomy, S. In vitro antifungal activity of clotrimazole (Bay b 5097). Infection and Immunity 4(2), 143-148 (1971). 3.Waitz, J.A.,Moss, E.L. and Weinstein, M.J. Chemotherapeutic evaluation of clotrimazole [Bay b 5097, 1 (o-chloro-α-α-diphenylbenzyl) imidazole]. Appl. Microbiol. 22(5), 891-898 (1971). 4.Fromtling, R.A. Overview of medically important antifungal azole derivatives. Clin.Microbiol.Rev. 1(2), 187-217 (1988). 5.Warrilow, A.G.,Melo, N.,Martel, C.M., et al. Expression, purification, and characterization of Aspergillus fumigatus sterol 14-a demethylase (CYP51) isoenzymes A and B. Antimicrobial Agents and Chemotherapy 54(10), 4225-4234 (2010). 6.Pegoraro, S.,Lang, M.,Dreker, T., et al. Inhibitors of potassium channels KV1.3 and IK-1 as immunosuppressants. Bioorganic & Medicinal Chemistry Letters 19(8), 2299-2304 (2009). | |
| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥98% |
| 计算分子量 | 344.8 |
| 分子式 | C22H17ClN2 |
| CAS号 | 23593-75-1 |
| 稳定性 | ≥ 2 years |
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