JK 184
货号：
15265-1mg 基本售价：
350.0 元 规格：
1 mg
产品信息
概述| 货号 | 15265-1mg |
| 描述 | JK 184 is an imidazopyridine derivative that inhibits downstream hedgehog signaling, preventing Gli-dependent transcriptional activity (IC50 = 30 nM).1 It does so by inhibiting alcohol dehydrogenase 7 (IC50 = 210 nM) and depolymerizing microtubules, preventing their assembly, which is crucial for Gli function.1,2 JK 184 exhibits antiproliferative activity in a range of cancer cell lines (L3.6pl, Panc 05.04, BxPC3, D283 med, Daoy; GI50s = 3-21 nM) and in L3.6pl and BxPC3 pancreatic cancer xenograft models (0.2 mg/mouse/day).1 |
性能| 供应商 | Cayman |
| 应用文献 |
1.Lee, J.,Wu, X.,Pasca de Magliano, M., et al. A small-molecule antagonist of the hedgehog signaling pathway. ChemBioChem 8(16), 1916-1919 (2007).
2.Cupido, T.,Rack, P.G.,Firestone, A.J., et al. The imidazopyridine derivative JK184 reveals dual roles for microtubules in hedgehog signaling. Angewandte Chemistry International Edition English 48(13), 2321-2324 (2009).
|
| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | 4 |
| 纯度 | ≥99% |
| 计算分子量 | 350.4 |
| 分子式 | C19H18N4OS |
| CAS号 | 315703-52-7 |
| 稳定性 | ≥ 1 year |
声明| 本官网所有报价均为常温或者蓝冰运输价格，如有产品需要干冰运输，需另外加收干冰运输费。 |
