GSK429286A
货号：
15262-1mg 基本售价：
350.0 元 规格：
1 mg
产品信息
概述| 货号 | 15262-1mg |
| 描述 | GSK429286A is a cell-permeable inhibitor of Rho-associated kinase (IC50 = 14 nM).1 It less potently inhibits p90 and p70 ribosomal S6 kinases (IC50s = 780 and 1,940 nM, respectively) and is ineffective against leucine-rich repeat protein kinase-2.1,2 GSK429286A reverses adrenalin-induced contraction of rat aortic rings (IC50 = 190 nM) and produces a dose-dependent decrease in mean arterial pressure in spontaneously-hypertensive rats.1 |
性能| 供应商 | Cayman |
| 应用文献 |
1.Goodman, K.B.,Cui, H.,Dowdell, S.E., et al. Development of dihydropyridone indazole amides as selective Rho-kinase inhibitors. Journal of Medicinal Chemistry 50(1), 6-9 (2007).
2.Nichols, R.J.,Dzamko, N.,Hutti, J.E., et al. Substrate specificity and inhibitors of LRRK2, a protein kinase mutated in Parkinson’s disease. Biochemistry Journal 424(1), 47-60 (2009).
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| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥98% |
| 计算分子量 | 432.4 |
| 分子式 | C21H16F4N4O2 |
| CAS号 | 864082-47-3 |
| 稳定性 | ≥ 2 years |
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