| 货号 | 15261-1mg |
| 描述 | AM580 is a retinoic acid receptor agonist that is selective for RARα (Kd = 8 nM; AC50 = 0.36 nM) compared to RARβ (Kd = 131 nM; AC50 = 24.6 nM) and RARγ (Kd = 450 nM; AC50 = 27.9 nM).1 It demonstrates greater specific binding to RARα compared to retinoic acid (Item No. 11017), which exhibits little selectivity across RARα, β, or γ.1,2,3 AM580 has been used in combination with the GSK3β inhibitor CHIR99021 (Item No. 13122) to efficiently induce differentiation of human induced pluripotent stem cells into immediate mesoderm.4 It can also inhibit the proliferation of various tumor cells, inhibiting survival signaling pathways and inducing apoptosis.5,6 |
| 别名 | CD336;NSC 608001;Ro 40-6055; |
| 供应商 | Cayman |
| 应用文献 | |
| 1.Bernard, B.A.,Bernardon, J.M.,Delescluse, C., et al. Identification of synthetic retinoids with selectivity for human nuclear retinoic acid receptor γ. Biochemical and Biophysical Research Communications 186(2), 977-983 (1992). 2.Kim, M.J.,Ciletti, N.,Michel, S., et al. The role of specific retinoid receptors in sebocyte growth and differentiation in culture. Journal of Investigative Dermatology 114, 349-353 (2000). 3.Rochette-Egly, C. and Germain, P. Dynamic and combinatorial control of gene expression by nuclear retinoic acid receptors (RARs). Nuclear Receptor Signaling 7, 1-18 (2009). 4.Araoka, T.,Mae, S.,Kurose, Y., et al. Efficient and rapid induction of human iPSCs/ESCs into nephrogenic intermediate mesoderm using small molecule-based differentiation methods. PLoS One 9(1), e84881 (2014). 5.Lu, Y.,Bertran, S.,Samuels, T.A., et al. Mechanism of inhibition of MMTV-neu and MMTV-wnt1 induced mammary oncogenesis by RARα agonist AM580. Oncogene 29(25), 3665-3676 (2010). 6.Cheng, Y.H.,Utsunomiya, H.,Pavone, M.E., et al. Retinoic acid inhibits endometrial cancer cell growth via multiple genomic mechanisms. Journal of Molecular Endocrinology 46(2), 139-153 (2011). | |
| 运输条件 | Wet ice in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥98% |
| 计算分子量 | 351.4 |
| 分子式 | C22H25NO3 |
| CAS号 | 102121-60-8 |
| 稳定性 | ≥ 2 years |
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