R 1530
货号：
15255-1mg 基本售价：
350.0 元 规格：
1 mg
产品信息
概述| 货号 | 15255-1mg |
| 描述 | R 1530 is a multi-kinase inhibitor that targets over 20 kinases, including angiogenesis-related receptor tyrosine kinases (Kds = 61, 88, and 15 nM for FGFR1, PDGFRβ, and VEGFR2, respectively).1 It also inhibits FLT1, KIT, PLK4, and RET with Kd values of 9, 26, 11, and 22 nM, respectively.1 In cells, R 1530 delays mitosis, induces polyploidy, and blocks angiogenesis, ultimately promoting apoptosis or senescence.1,2 R 1530 strongly inhibits human tumor cell proliferation and reduces the growth of tumors in cancer xenograft models.3 |
性能| 供应商 | Cayman |
| 应用文献 |
1.Liu, J.-J.,Higgins, B.,Ju, G., et al. Discovery of a highly potent, orally active mitosis/angiogenesis inhibitor r1530 for the treatment of solid tumors. ACS Med. Chem. Lett. 4(2), 259-263 (2013).
2.Tovar, C.,Higgins, B.,Deo, D.D., et al. Small-molecule inducer of cancer cell polyploidy promotes apoptosis or senescence: Implications for therapy. Cell Cycle 9(16), 3364-3375 (2010).
3.Kolinsky, K.,Tovar, C.,Zhang, Y.-E., et al. Preclinical evaluation of the novel multi-targeted agent R1530. Cancer Chemother. Pharmacol. 68(6), 1585-1594 (2011).
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| 运输条件 | Wet ice in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥98% |
| 计算分子量 | 356.8 |
| 分子式 | C18H14ClFN4O |
| CAS号 | 882531-87-5 |
| 稳定性 | ≥ 2 years |
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