| 货号 | 15252-50mg |
| 描述 | 1-aminobenzotriazole (ABT) is a non-specific cytochrome P450 (CYP) inhibitor.1,2,3 It does not appear to affect other enzymes, including UDP-glucuronosyltransferases.4,5 ABT acts as a CYP suicide substrate, producing maximal destruction of hepatic and renal microsome CYP protein in vitro at 10 mM.4 It is effective in vivo, significantly reducing CYP content in both liver and kidney in rats within two hours.4 The effects of ABT on CYP activity is time-dependent, with significant shift in IC50 values with preincubation.3 |
| 别名 | ABT;3-Aminobenzotriazole;1-Benzotriazolylamine;NSC 114498;NSC 656987; |
| 供应商 | Cayman |
| 应用文献 | |
| 1.Ma, L.-l.,Wu, Z.-t.,Wang, L., et al. Inhibition of hepatic cytochrome P450 enzymes and sodium/bile acid cotransporter exacerbates leflunomide-induced hepatotoxicity. Acta. Pharmacol. Sin. 37(3), 415-424 (2016). 2.Miyakawa, K.,Albee, R.,Letzig, L.G., et al. A cytochrome P450-independent mechanism of acetaminophen-induced injury in cultured mouse hepatocytes. J. Pharmacol. Exp. Ther. 354(2), 230-237 (2015). 3.Emoto, C.,Murase, S.,Sawada, Y., et al. In vitro inhibitory effect of 1-aminobenzotriazole on drug oxidations in human liver microsomes: A comparison with SKF-525A. Drug Metab.Pharmacokinet. 20(5), 351-357 (2005). 4.Mugford, C.A.,Mortillo, M.,Mico, B.A., et al. 1-Aminobenzotriazole-induced destruction of hepatic and renal cytochromes P450 in male Sprague-Dawley rats. Fundam. Appl. Toxicol. 19(1), 43-49 (1992). 5.Walsky, R.L.,Bauman, J.N.,Bourcier, K., et al. Optimized assays for human UDP-glucuronosyltransferase (UGT) activities: altered alamethicin concentration and utility to screen for UGT inhibitors. Drug Metabolism and Disposition 40(5), 1051-1065 (2012). | |
| 运输条件 | Wet ice in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥98% |
| 计算分子量 | 134.1 |
| 分子式 | C6H6N4 |
| CAS号 | 1614-12-6 |
| 稳定性 | ≥ 2 years |
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