| 货号 | 15249-25mg |
| 描述 | The L-type amino acid transporters (LATs) are Na+-dependent neutral amino acid transporters.1 They include four members in two sub-families, with LAT1 and LAT2 belonging to solute carrier (SLC) family 7 and LAT3 and LAT4 being members of SLC43.1 LAT1 is overexpressed in many tumors and contributes to ribosome biogenesis and cell growth by supporting mTOR complex 1 (mTORC1) signaling.2 BCH is an inhibitor of LAT1 that blocks the uptake of L-leucine with an IC50 value of 131.5 µM.3,4 It can inhibit all members of the LAT family at a concentration of 10 mM.1 In addition to eliminating the uptake of neutral amino acids, BCH suppresses mTORC1 signaling that drives DNA synthesis and cell proliferation.1,2 LAT1 is also essential for the uptake of amino acid-related compounds, like L-DOPA (Item No. 13248), through the blood-brain barrier, and this can be inhibited by BCH.4,5 |
| 别名 | 2-amino-2-Norbornanecarboxylic Acid; |
| 供应商 | Cayman |
| 应用文献 | |
| 1.Wang, Q. and Holst, J. L-type amino acid transport and cancer: Targeting the mTORC1 pathway to inhibit neoplasia. Am.J.Cancer Res. 5(4), 1281-1294 (2015). 2.Dann, S.G.,Selvaraj, A. and Thomas, G. mTOR complex1-S6K1 signaling: At the crossroads of obesity, diabetes and cancer. Trends in Molecular Medicine N/A, 1-8 (2007). 3.Fraga, S.,Serrao, M.P. and Soares-Da-Silva, P. L-type amino acid transporters in two intestinal epithelial cell lines function as exchangers with neutral amino acids. Journal of Nutrition 132(4), 733-738 (2002). 4.Kim, D.K.,Kanai, Y.,Choi, H.W., et al. Characterization of the system L amino acid transporter in T24 human bladder carcinoma cells. Biochim Biophys.Acta. 1565(1), 112-121 (2002). 5.Kageyama, T.,Nakamura, M.,Matsuo, A., et al. The 4F2hc/LAT1 complex transports L-DOPA across the blood-brain barrier. Brain Research 879(1-2), 115-121 (2000). | |
| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥98% |
| 计算分子量 | 155.2 |
| 分子式 | C8H13NO2 |
| CAS号 | 20448-79-7 |
| 稳定性 | ≥ 2 years |
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