| 货号 | 15246-100mg |
| 描述 | Fisetin is a natural flavonol that is structurally and functionally related to kaempferol (Item No. 11852), myricetin (Item No. 10012600), and quercetin (Item No. 10005169). All are potent antioxidants and have anti-inflammatory actions with possible relevance to cancer.1,2,3 Fisetin and other flavonols act as activators of sirtuin 1, inhibitors of the spleen tyrosine kinase SYK, and suppressors of CD36 gene expression.4,5,6 |
| 别名 | CI-75620;NSC 407010;NSC 656275; |
| 供应商 | Cayman |
| 应用文献 | |
| 1.van Acker, F.A.A.,Schouten, O.,Haenen, G.R.M.M., et al. Flavonoids can replace α-tocopherol as an antioxidant. FEBS Letters 473, 145-148 (2000). 2.Duthie, G. and Morrice, P. Antioxidant capacity of flavonoids in hepatic microsomes is not reflected by antioxidant effects in vivo. Oxid.Med.Cell.Longev. 2012, 1-7 (2012). 3.Gupta, S.C.,Kim, J.H.,Prasad, S., et al. Regulation of survival, proliferation, invasion, angiogenesis, and metastasis of tumor cells through modulation of inflammatory pathways by nutraceuticals. Cancer Metastasis Reviews 29(3), 405-434 (2010). 4.Szczepankiewicz, B.G. and Ng, P.Y. Sirtuin modulators: Targets for metabolic diseases and beyond. Current Topics in Medicinal Chemistry 8(17), 1533-1544 (2008). 5.Singh, R.,Masuda, E.S. and Payan, D.G. Discovery and development of spleen tyrosine kinase (SYK) inhibitors. Journal of Medicinal Chemistry 55(8), 3614-3643 (2012). 6.Lian, T.-W.,Wang, L.,Lo, Y.-H., et al. Fisetin, morin and myricetin attenuate CD36 expression and oxLDL uptake in U937-derived macrophages. Biochimica et Biophysica Acta 1781, 601-609 (2008). | |
| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥90% |
| 计算分子量 | 286.2 |
| 分子式 | C15H10O6 |
| CAS号 | 528-48-3 |
| 稳定性 | ≥ 2 years |
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