ML-090
货号：
15172-10mg 基本售价：
350.0 元 规格：
10 mg
产品信息
概述| 货号 | 15172-10mg |
| 描述 | NADPH oxidase 1 (NOX1) generates reactive oxygen species (ROS) in colon epithelial cells that interacts with both pathogenic and normal bacteria. Excess ROS production, however, is associated with damage to the intestinal mucosa, inflammatory bowel disease, and prostate cancer.1 ML-090 is the first identified NOX1-specific inhibitor (IC50 = 360 nM in HEK293 cells) based on a quinoxaline scaffold that demonstrates potent selectivity over NOX2, NOX3, and NOX4 (IC50s ≥ 10 µM) and xanthine oxidase (IC50 = 3.5 µM).1 |
| 别名 | CCG-44699;CID-616479;Fluoflavin;NSC 179821; |
性能| 供应商 | Cayman |
| 应用文献 |
1.Brown, S.J.,Gianni, D.,Bokoch, G., et al. Probe report for NOX1 inhibitors. 1-7 (2009).
|
| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥95% |
| 计算分子量 | 234.3 |
| 分子式 | C14H10N4 |
| CAS号 | 531-46-4 |
| 稳定性 | ≥ 2 years |
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