| 货号 | 15023-50mg |
| 描述 | Prazosin is an antihypertensive agent that blocks postsynaptic α1-adrenergic receptors in the periphery (IC50 = 0.20 nM in dog aorta) and is capable of crossing the blood-brain barrier, decreasing sympathetic outflow in the brain (IC50 = 1.7 nM in rat brain).1,2 Prazosin is also a potent antagonist at the melatonin MT3 receptor (Ki = 10.2 - 12.4 nM; IC50 = 7.8 nM in hamster).3,4 |
| 别名 | Adversuten;CP 12,299-1;NSC 292810; |
| 供应商 | Cayman |
| 应用文献 | |
| 1.Nagatomo, T.,Tsuchihashi, H.,Sasaki, S., et al. Displacement by α-adrenergic agonists and antagonists of 3H-prazosin bound to the α-adrenoceptors of the dog aorta and the rat brain. Japan J.Pharmacol. 37, 181-187 (1985). 2.Kristek, F. and Koprdova, R. Long-term effect of prazosin administration on blood pressure, heart and structure of coronary artery of young spontaneously hypertensive rats. Journal of Physiology and Pharmacology 62(3), 295-301 (2011). 3.Paul, P.,Lahaye, C.,Delagrange, P., et al. Characterization of 2-[125]iodomelatonin binding sites in Syrian hamster peripheral organs. Journal of Pharmacology and Experimental Therapeutics 290(1), 334-340 (1999). 4.Pegan, S.D.,Sturdy, M.,Ferry, G., et al. X-ray structural studies of quinone reductase 2 nanomolar range inhibitors. Protein Science 20, 1182-1195 (2011). | |
| 运输条件 | Wet ice in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥98% |
| 计算分子量 | 419.9 |
| 分子式 | C19H21N5O4 • HCl |
| CAS号 | 19237-84-4 |
| 稳定性 | ≥ 2 years |
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