| 货号 | 14976-1mg |
| 描述 | TAS 301 (10 μM) impedes Ca2+ mobilization and Ca2+/calmodulin-dependent protein kinase II (CaM kinase II) activation that inhibits vascular smooth muscle cell (VSMC) proliferation in vitro.1,2 At a concentration of 10 μM, TAS 301 also inhibits platelet-derived growth factor (PDGF)-induced tyrosine phosphorylation of focal adhesion kinase and paxillin and promotes cytoskeletal rearrangment.1 TAS 301 (3-100 mg/kg) inhibits migration and proliferation of VSMCs and prevents arterial intimal thickening in vivo in a model of balloon-injured arteries in rats.3 In a micro pig model, TAS 301 administration (30-100 mg/kg) prevents coronary artery stenosis after balloon overstretch injury.4 |
| 供应商 | Cayman |
| 应用文献 | |
| 1.Sasaki, E.,Miyoshi, K.,Nozawa, Y., et al. Tas-301, a new synthetic inhibitor of neointimal thickening after balloon injury, inhibits calcium-dependent signal transduction and cytoskeletal reorganization. Pharmacology 63(1), 17-27 (2001). 2.Sasaki, E.,Nozawa, Y.,Miyoshi, K., et al. TAS-301 blocks receptor-operated calcium influx and inhibits rat vascular smooth muscle cell proliferation induced by basic fibroblast growth factor and platelet-derived growth factor. Jpn. J. Pharmacol. 84(3), 252-258 (2000). 3.Muranaka, Y.,Yamasaki, Y.,Nozawa, Y., et al. TAS-301, an inhibitor of smooth muscle cell migration and proliferation, inhibits intimal thickening after balloon injury to rat carotid arteries. J. Pharmacol. Exp. Ther. 285(3), 1280-1286 (1998). 4.Sasaki, E.,Tanahashi, Y.,Yamasaki, Y., et al. Inhibitory effect of TAS-301, a new synthesized constrictive remodeling regulator, on renarrowing after balloon overstretch injury of porcine coronary artery. J. Pharmacol. Exp. Ther. 295(3), 1043-1050 (2000). | |
| 运输条件 | Wet ice in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥98% |
| 计算分子量 | 357.4 |
| 分子式 | C23H19NO3 |
| CAS号 | 193620-69-8 |
| 稳定性 | ≥ 2 years |
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