| 货号 | 14929-1mg |
| 描述 | Macrophage migration inhibitory factor (MIF) is a regulator of inflammation that also has roles in cancer and autoimmune diseases.1 MIF exhibits both tautomerase and oxidoreductase activities, although how these are linked to MIF’s physiological and pathophysiological actions is unclear.1 MIF antagonist, also known as ISO-1, is an inhibitor of the dopachrome tautomerase activity of MIF in vitro(IC50 = 7 µM) and in cells (IC50 = 25 µM).2,3 It blocks the activation of NF-κB and TNF-α secretion from LPS-treated macrophages and improves the survival of mice following sepsis.3 MIF antagonist also demonstrates protective effects in airway and gastrointestinal inflammation in mice.4,5 |
| 别名 | ISO-1;Macrophage Migration Inhibitory Factor; |
| 供应商 | Cayman |
| 应用文献 | |
| 1.Xu, L.,Li, Y.,Sun, H., et al. Current developments of macrophage migration inhibitory factor (MIF) inhibitors. Drug Discovery Today 18(11-12), 592-600 (2013). 2.Lubetsky, J.B.,Dios, A.,Han, J., et al. The tautomerase active site of macrophage migration inhibitory factor is a potential target for discovery of novel anti-inflammatory agents. The Journal of Biological Chemisty 277(28), 24976-24982 (2002). 3.Al-Abed, Y.,Dabideen, D.,Aljabari, B., et al. ISO-1 binding to the tautomerase active site of MIF inhibits its pro-inflammatory activity and increases survival in severe sepsis. The Journal of Biological Chemisty 280(44), 36541-36544 (2005). 4.Dagia, N.M.,Kamath, D.V.,Bhatt, P., et al. A fluorinated analog of ISO-1 blocks the recognition and biological function of MIF and is orally efficacious in a murine model of colitis. European Journal of Pharmacology 607(1-3), 201-212 (2009). 5.Chen, P.F.,Luo, Y.l.,Wang, W., et al. ISO-1, a macrophage migration inhibitory factor antagonist, inhibits airway remodeling in a murine model of chronic asthma. Molecular Medicine 16(9-10), 400-408 (2010). | |
| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥95% |
| 计算分子量 | 235.2 |
| 分子式 | C12H13NO4 |
| CAS号 | 478336-92-4 |
| 稳定性 | ≥ 2 years |
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