PF-573228
货号：
14924-1mg 基本售价：
350.0 元 规格：
1 mg
产品信息
概述| 货号 | 14924-1mg |
| 描述 | Focal adhesion kinases (FAKs) are non-receptor tyrosine kinases that play roles in regulating diverse processes, including cell adhesion, spreading, migration, proliferation, and apoptosis.1 They are overexpressed in many types of cancer. PF-573228 inhibits FAK with IC50 values of 4 and 30-100 nM for a purified recombinant catalytic fragment of FAK and in cultured cells, respectively.2 It is 50-250-fold selective for FAK over other protein kinases.2 PF-573228 can inhibit chemotactic and haptotactic migration of cells as well as prevent focal adhesion turnover.3 |
| 别名 | FAK Inhibitor II;Focal Adhesion Kinase Inhibitor II; |
性能| 供应商 | Cayman |
| 应用文献 |
1.Parsons, J.T.,Slack-Davis, J.,Tilghman, R., et al. Focal adhesion kinase: Targeting adhesion signaling pathways for therapeutic intervention. Clinical Cancer Research 14(3), 627-632 (2008).
2.Medina, J.F.,Haeggström, J.,Kumlin, M., et al. Leukotriene A4: Metabolism in different rat tissues. Biochemica et Biophysica Acta 961, 203-212 (1988).
3.Slack-Davis, J.K.,Martin, K.H.,Tilghman, R.W., et al. Cellular characterization of a novel focal adhesion kinase inhibitor. The Journal of Biological Chemisty 282(20), 14845-14852 (2007).
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| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥95% |
| 计算分子量 | 491.5 |
| 分子式 | C22H20F3N5O3S |
| CAS号 | 869288-64-2 |
| 稳定性 | ≥ 2 years |
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