Calpain Inhibitor I
货号：
14921-1mg 基本售价：
350.0 元 规格：
1 mg
产品信息
概述| 货号 | 14921-1mg |
| 描述 | Calpain inhibitor I is a synthetic tripeptide aldehyde that acts as a potent inhibitor of cysteine proteases including calpain I (Ki = 190 nM), calpain II (Ki = 220 nM), cathepsin B (Ki = 150 nM), and cathepsin L (Ki = 500 pM).1 At 10-100 μM calpain inhibitor I dose-dependently prevents the degradation of IκBα and IκBβ by the ubiquitin-proteasome complex, which blocks activation of NFκB and the production of TNF and IL-1β, suggesting a potential therapeutic effect for inflammatory diseases.2 At 10 μM, calpain inhibitor I can inhibit nitric oxide production by activated macrophages by interfering with transcription of the inducible nitric oxide synthase gene.3 |
| 别名 | Ac-Leu-Leu-Nle-Aldehyde;ALLN;MG 101; |
性能| 供应商 | Cayman |
| 应用文献 |
1.Sasaki, T.,Kishi, M.,Saito, M., et al. Inhibitory effect of di- and tripeptidyl aldehydes on calpains and cathepsins. Journal of Enzyme Inhibition 3(3), 195-201 (1990).
2.Haas, M.,Page, S.,Page, M., et al. Effect of proteasome inhibitors on monocytic IκB-α and -β depletion, NF-κB activation, and cytokine production. Journal of Leukocyte Biology 63(3), 395-404 (1998).
3.Griscavage, J.M.,Wilk, S. and Ignarro, L.J. Serine and cysteine proteinase inhibitors prevent nitric oxide production by activated macrophages by interfering with transcription of the inducible NO synthase gene. Biochemical and Biophysical Research Communications 215(2), 721-729 (1995).
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| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥95% |
| 计算分子量 | 383.5 |
| 分子式 | C20H37N3O4 |
| CAS号 | 110044-82-1 |
| 稳定性 | ≥ 2 years |
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