MeOSuc-Ala-Ala-Pro-Val-AMC
货号：
14907-1mg 基本售价：
350.0 元 规格：
1 mg
产品信息
概述| 货号 | 14907-1mg |
| 描述 | MeOSuc-Ala-Ala-Pro-Val-AMC (MeOSuc-AAPV-AMC) is a fluorogenic substrate for human leukocyte and porcine pancreatic elastase. The methoxy succinyl (MeO-Suc) peptide AAPV is avidly hydrolyzed by these elastases but not by cathepsin G.1,2 The addition of 7-amino-4-methylcoumarin (AMC) generates a peptide of low fluorescence (excitation: 355-380 nm; emission 440-460 nm) that demonstrates a linear increase in fluorescence in the presence of elastase.3 This peptidyl-AMC substrate detects as little as 11 pM human leukocyte elastase and 18 pM porcine pancreatic elastase.3 |
| 别名 | I 1270;MeOSuc-AAPV-AMC;Methoxy Succinyl-Ala-Ala-Pro-Val-AMC; |
性能| 供应商 | Cayman |
| 应用文献 |
1.Powers, J.C.,Gupton, B.F.,Harley, A.D., et al. Specificity of porcine pancreatic elastase, human leukocyte elastase and cathepsin G. Inhibition with peptide chloromethyl ketones. Biochim.Biophys.Acta. 485(1), 156-166 (1977).
2.Nakajima, K. and Powers, J.C. Mapping the extended substrate binding site of cathepsin G and human leukocyte elastase. The Journal of Biological Chemisty 254(10), 4027-4032 (1979).
3.Castillo, M.J.,Nakajima, K.,Zimmerman, M., et al. Sensitive substrates for human leukocyte and porcine pancreatic elastase: A study of the merits of various chromophoric and fluorogenic leaving groups in assays for serine proteases. Analytical Biochemistry 99(1), 53-64 (1979).
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| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥98% |
| 计算分子量 | 627.7 |
| 分子式 | C31H41N5O9 |
| CAS号 | 72252-90-5 |
| 稳定性 | ≥ 2 years |
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