| 货号 | 14906-25mg |
| 描述 | Meloxicam is a non-steroidal anti-inflammatory drug (NSAID) with selectivity for COX-2 (IC50 = 11.8 μM) over COX-1 (IC50 = 143 μM) in in vitroassays.1 It shows potent anti-inflammatory, antipyretic, and analgesic effects with low gastrointestinal toxicity in animal models.1,2,3 In adjuvant arthritis in the rat, meloxicam has been shown to inhibit acute exudation and leukocyte migration as well as to prevent bone and cartilage destruction.4 Additionally, in clinical studies, meloxicam has shown reliable efficacy against rheumatoid arthritis.5 |
| 别名 | Coxicam;UH-AC 62XX; |
| 供应商 | Cayman |
| 应用文献 | |
| 1.Ogino, K.,Hatanaka, K.,Kawamura, M., et al. Evaluation of pharmacological profile of meloxicam as an anti-inflammatory agent, with particular reference to its relative selectivity for cyclooxygenase-2 over cyclooxygenase-1. Pharmacology 55, 44-53 (1997). 2.Jones, C.J.,Streppa, H.K.,Harmon, B.G., et al. In vivo effects of meloxicam and aspirin on blood, gasteric mucosal, and synovial fluid prosanoid synthesis in dogs. American Journal of Veterinary Research 63, 1527-1531 (2002). 3.Cruz, R.,Quintana-Hau, J.D.,González, J.R., et al. Effects of an ophthalmic formulation of meloxicam on COX-2 expression, PGE2 release, and cytokine expression in a model of acute ocular inflammation. British Journal of Ophthalmology 92, 120-125 (2008). 4.Engelhardt, G. Pharmacology of meloxicam, a new non-steroidal anti-inflammatory drug with an improved safety profile through preferential inhibition of COX-2. British Journal of Rheumatology 35(1), 4-12 (1996). 5.Lemmel, E.M.,Bolten, W.,Burgos-Vargas, R., et al. Efficacy and safety of meloxicam in patients with rheumatoid arthritis. Journal of Rheumatology 24, 282-290 (1997). | |
| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥95% |
| 计算分子量 | 351.4 |
| 分子式 | C14H13N3O4S2 |
| CAS号 | 71125-38-7 |
| 稳定性 | ≥ 2 years |
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