NU 7441
货号：
14881-1mg 基本售价：
350.0 元 规格：
1 mg
产品信息
概述| 货号 | 14881-1mg |
| 描述 | DNA-dependent protein kinase (DNA-PK) catalyzes nonhomologous end-joining, which is required to repair lethal DNA double-strand breaks. Because cells that are defective in DNA double-strand break repair are highly sensitive to ionizing radiation and topoisomerase II poisons, modulating DNA-PK is one strategy to defer cancer cell resistance to radiation or chemotherapeutic treatments.1 NU 7441 is a selective DNA-PK inhibitor with an IC50 value of 14 nM.2 It inhibits other members of the PI3K-related kinase family, including mTOR, PI3K, ataxia telangiectasia mutated (ATM), and ataxia telangiectasia and Rad3 related (ATR) with IC50 values of 1.7, 5, >100, and >100 μM, respectively.2 NU 7441 has been shown to increase the cytotoxicity of ionizing radiation and etoposide (Item No. 12092) in human colon cancer cell lines in vitro and to potentiate the effects of etoposide in mice bearing human colon cancer xenograft tumors in vivo.3 |
| 别名 | Ku-57788; |
性能| 供应商 | Cayman |
| 应用文献 |
1.Veuger, S.J.,Curtin, N.J.,Richardson, C.J., et al. Radiosensitization and DNA repair inhibition by the combined use of novel inhibitors of DNA-dependent protein kinase and poly(ADP-ribose) polymerase-1. Cancer Research 63, 6008-6015 (2003).
2.Leahy, J.J.J.,Golding, B.T.,Griffin, R.J., et al. Identification of a highly potent and selective DNA-dependent protein kinase (DNA-PK) inhibitor (NU7441) by screening of chromenone libraries. Bioorganic & Medicinal Chemistry Letters 14(24), 6083-6087 (2004).
3.Zhao, Y.,Thomas, H.D.,Batey, M.A., et al. Preclinical evaluation of a potent novel DNA-dependent protein kinase inhibitor NU7441. Cancer Research 66(10), 5354-5362 (2006).
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| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥98% |
| 计算分子量 | 413.5 |
| 分子式 | C25H19NO3S |
| CAS号 | 503468-95-9 |
| 稳定性 | ≥ 2 years |
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