| 货号 | 14877-1g |
| 描述 | 2,2,6,6-tetramethylpiperidin-1-oxyl (TEMPO) is a stable radical that will react with reactive oxygen species (ROS).1 This conversion, followed by ESR, provides an indirect way to monitor ROS production in biological systems. TEMPONE is the 4-oxo derivative of TEMPO. In addition to possible uses as a spin trap, this nitroxyl radical can be used in hydrogen transfer experiments and as a polarizing agent in dynamic nuclear polarization NMR spectroscopy.2,3 TEMPONE and other nitroxyl radicals have also been shown to reduce mean arterial pressure in spontaneously hypertensive rats when administered intravenously.4 |
| 别名 | 4-oxo-TEMPO;Triacetoneamine nitroxide; |
| 供应商 | Cayman |
| 应用文献 | |
| 1.Ban, S.,Nakagawa, H.,Suzuki, T., et al. Novel mitochondria-localizing TEMPO derivative for measurement of cellular oxidative stress in mitochondria. Bioorganic & Medicinal Chemistry Letters 17, 2055-2058 (2007). 2.Wu, A.,Mader, E.A.,Datta, A., et al. Nitroxyl radical plus hydroxylamine pseudo self-exchange reactions: Tunneling in hydrogen atom transfer. Journal of the American Chemical Society 131(33), 11985-11997 (2009). 3.Lumata, L.,Merritt, M.,Khemtong, C., et al. The efficiency of DPPH as a polarising agent for DNP-NMR spectroscopy. RSC Adv. 2(33), 12812-12817 (2012). 4.Patel, K.,Chen, Y.,Dennehy, K., et al. Acute antihypertensive action of nitroxides in the spontaneously hypertensive rat. American Journal of Physiology.Regulatory, Integrative and Comparative Physiology 290(1), R37-R43 (2006). | |
| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥98% |
| 计算分子量 | 170.2 |
| 分子式 | C9H16NO2 |
| CAS号 | 2896-70-0 |
| 稳定性 | ≥ 2 years |
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