HA-14-1
货号：
14876-5mg 基本售价：
350.0 元 规格：
5 mg
产品信息
概述| 货号 | 14876-5mg |
| 描述 | HA-14-1 is a small molecule that binds the surface pocket of Bcl-2 proteins (IC50 = ~ 9 µM) and induces apoptosis by interfering with its interaction with the Bak peptide and activating Apaf-1 and caspase-9 and -3.1 It can also bind to the antiapoptotic Bcl-2 proteins Bcl-xl and Bcl-W.2 HA-14-1 has been shown to induce apoptosis of human acute myeloid leukemia (HL-60) cells (50 µM induces 90% loss of viability).1 |
性能| 供应商 | Cayman |
| 应用文献 |
1.Wang, J.L.,Liu, D.,Zhang, Z.J., et al. Structure-based discovery of an organic compound that binds Bcl-2 protein and induces apoptosis of tumor cells. Proceedings of the National Academy of Sciences of the United States of America 97(13), 7124-7129 (2000).
2.Azmi, A.S. and Mohammad, R.M. Non-peptidic small molecule inhibitors against Bcl-2 for cancer therapy. J.Cell Physiol. 218(1), 13-21 (2009).
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| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥98% |
| 计算分子量 | 409.2 |
| 分子式 | C17H17BrN2O5 |
| CAS号 | 65673-63-4 |
| 稳定性 | ≥ 2 years |
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