| 货号 | 14862-500ug |
| 描述 | Nuclear factor-κB (NF-κB) is a protein complex which modulates gene transcription relevant to cellular responses to inflammation, stress, infection, and other factors.1 The inhibitor of NF-κB kinase β (IKKβ), in complex with IKKα and IKKγ, phosphorylates inhibitor of NF-κB A and B (IκA and IκB) and other proteins involved in NF-κB signaling, and thus plays a central regulatory role.1 PS-1145 is a potent inhibitor of IKKβ (IC50 = 88-100 nM).2,3 Through this action, it is used to elucidate roles for NF-κB both in cells and in vivo.2,4,5,6 |
| 别名 | IKK Inhibitor X; |
| 供应商 | Cayman |
| 应用文献 | |
| 1.Perkins, N.D. Integrating cell-signalling pathways with NF-κB and IKK function. Nature Reviews.Molecular Cell Biology 8(1), 49-62 (2011). 2.Hideshima, T.,Chauhan, D.,Richardson, P., et al. NF-κB as a therapeutic target in multiple myeloma. The Journal of Biological Chemisty 277(19), 16639-16647 (2002). 3.Castro, A.C.,Dang, L.C.,Soucy, F., et al. Novel IKK inhibitors: β-carbolines. Bioorganic & Medicinal Chemistry Letters 13(14), 2419-2422 (2003). 4.Oh-I, S.,Thaler, J.P.,Ogimoto, K., et al. Central administration of interleukin-4 exacerbates hypothalamic inflammation and weight gain during high-fat feeding. American Journal of Physiology.Endocrinology and Metabolism 299(1), E47-E53 (2010). 5.Gancz, D.,Lusthaus, M. and Fishelson, Z. A role for the NFκB pathway in cell protection from complement-dependent cytotoxicity. Journal of Immunology 189(2), 860-866 (2012). 6.Wang, C.Z.,Li, B.,Wen, X.D., et al. Paraptosis and NF-κB activation are associated with protopanaxadiol-induced cancer chemoprevention. BMC Complement.Altern.Med. 13, 2-8 (2013). | |
| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥98% |
| 计算分子量 | 322.8 |
| 分子式 | C17H11ClN4O |
| CAS号 | 431898-65-6 |
| 稳定性 | ≥ 2 years |
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