NSC 405020
货号：
14859-1mg 基本售价：
350.0 元 规格：
1 mg
产品信息
概述| 货号 | 14859-1mg |
| 描述 | NSC 405020 binds to the hemopexin (PEX) domain of the membrane type-1 matrix metalloproteinase (MT1-MMP/MMP-14).1 It disrupts MT1-MMP homodimerization without affecting its catalytic activity in an assay using the MT1-MMP CAT domain, which is involved in its tumor promoting function (IC50 > 100 µM). In a mouse tumor xenograft model, it reduces tumor growth through a cell death-independent mechanism when injected intratumorally at a dose of 0.5 mg/kg three times per week for two weeks. NSC 405020 (1 µM) applied to HSC5 cells prevents arsenic-mediated invasion while also decreasing the expression of MT1-MMP and pERK.2 |
性能| 供应商 | Cayman |
| 应用文献 |
1.Remacle, A.G.,Golubkov, V.S.,Shiryaev, S.A., et al. Novel MT1-MMP small-molecule inhibitors based on insights into hemopexin domain function in tumor growth. Cancer Res. 72(9), 2339-2349 (2012).
2.Thang, N.D.,Yajima, I.,Kumasaka, M.Y., et al. Bidirectional functions of arsenic as a carcinogen and an anti-cancer agent in human squamous cell carcinoma. PLoS One 9(5), e96945 (2014).
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| 运输条件 | Wet ice in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥98% |
| 计算分子量 | 260.2 |
| 分子式 | C12H15Cl2NO |
| CAS号 | 2044451 |
| 稳定性 | ≥ 2 years |
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