| 货号 | 14842-10mg |
| 描述 | Mitoxantrone is an anthraquinone that intercalates in DNA and inhibits topoisomerase II (IC50 = 5.3 μM), thus inhibiting cell proliferation.1,2 It also inhibits HIV-1 integrase (IC50 = 3.8 μM).3 Mitoxantrone is exported from cells in an ATP- and glutathione-dependent manner by multidrug resistance protein -1.4 This compound has found use in various forms of cancer and in multiple sclerosis.5,6,7 |
| 别名 | NCI 301739;Novantrone;NSC 301739; |
| 供应商 | Cayman |
| 应用文献 | |
| 1.Fox, M.E. and Smith, P.J. Long-term inhibition of DNA synthesis and the persistence of trapped topoisomerase II complexes in determining the toxicity of the antitumor DNA intercalators mAMSA and mitoxantrone. Cancer Research 50(18), 5813-5818 (1990). 2.Hasinoff, B.B.,Liang, H.,Wu, X., et al. The structure-based design, synthesis and biological evaluation of DNA-binding bisintercalating bisanthrapyrazole anticancer compounds. Bioorganic & Medicinal Chemistry 16(7), 3959-3968 (2008). 3.Carlson, H.A.,Masukawa, K.M.,Rubins, K., et al. Developing a dynamic pharmacophore model for HIV-1 integrase. Journal of Medicinal Chemistry 43(111), 2100-2114 (2000). 4.Morrow, C.S.,Peklak-Scott, C.,Bishwokarma, B., et al. Multidrug resistance protein 1 (MRP1, ABCC1) mediates resistance to mitoxantrone via glutathione-dependent drug efflux. Molecular Pharmacology 69(4), 1499-1505 (2006). 5.Garcia, J.A. and Rini, B.I. Castration-resistant prostate cancer: Many treatments, many options, many challenges ahead. Cancer 118(10), 2583-2593 (2012). 6.Lu, E.,Wang, B.W.,Guimond, C., et al. Safety of disease-modifying drugs for multiple sclerosis in pregnancy: Current challenges and future considerations for effective pharmacovigilance. Expert Rev.Neurother. 13(3), 251-260 (2013). 7.Marriott, J.J.,Miyasaki, J.M.,Gronseth, G., et al. Evidence report: The efficacy and safety of mitoxantrone (Novantrone) in the treatment of multiple sclerosis. Neurology 74(18), 1463-1470 (2010). | |
| 运输条件 | Wet ice in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥95% |
| 计算分子量 | 517.4 |
| 分子式 | C22H28N4O6 • 2HCl |
| CAS号 | 70476-82-3 |
| 稳定性 | ≥ 2 years |
| 本官网所有报价均为常温或者蓝冰运输价格，如有产品需要干冰运输，需另外加收干冰运输费。 |