| 货号 | 14832-1mg |
| 描述 | Inhibitors of phosphodiesterase 4 (PDE4), which catalyzes the hydrolysis of cAMP, have potential applications in a variety of diseases, including asthma.1 Ibudilast is an inhibitor of PDE4 (IC50 = 54-239 nM) that, at higher doses, also inhibits PDE3 and PDE5 (IC50 = 1,600-3,510 nM).2,3 Through this action, it suppresses the elaboration of mediators involved in asthma and inflammation.2,4,5 |
| 别名 | AV 411;KC-404; |
| 供应商 | Cayman |
| 应用文献 | |
| 1.Spina, D. PDE4 inhibitors: Current status. British Journal of Pharmacology 155, 308-315 (2008). 2.Huang, Z.,Liu, S.,Zhang, L., et al. Preferential inhibition of human phosphodiesterase 4 by ibudilast. Life Sciences 78(23), 2663-2668 (2006). 3.Allcock, R.W.,Blakli, H.,Jiang, Z., et al. Phosphodiesterase inhibitors. Part 1: Synthesis and structure-activity relationships of pyrazolopyridine-pyridazinone PDE inhibitors developed from ibudilast. Bioorganic & Medicinal Chemistry Letters 21(11), 3307-3312 (2011). 4.Kodimuthali, A.,Jabaris, S.S.L. and Pal, M. Recent advances on phosphodiesterase 4 inhibitors for the treatment of asthma and chronic obstructive pulmonary disease. Journal of Medicinal Chemistry 51(18), 5471-5489 (2008). 5.Souness, J.E.,Villamil, M.E.,Scott, L.C., et al. Possible role of cyclic AMP phosphodiesterases in the actions of ibudilast on eosinophil thromboxane generation and airways smooth muscle tone. British Journal of Pharmacology 111(4), 1081-1088 (1994). | |
| 运输条件 | Wet ice in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥98% |
| 计算分子量 | 230.3 |
| 分子式 | C14H18N2O |
| CAS号 | 50847-11-5 |
| 稳定性 | ≥ 2 years |
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