Syk Inhibitor
货号：
14829-500ug 基本售价：
350.0 元 规格：
500 ug
产品信息
概述| 货号 | 14829-500ug |
| 描述 | Spleen tyrosine kinase (Syk) is a non-receptor tyrosine kinase that upon phosphorylation binds to immunoreceptor tyrosine-based activation motifs (ITAMs) of FcRγ chains and mediates downstream signaling related to platelet function and inflammation.1 Syk inhibitor is an oxindole compound that potently blocks Syk activity with an IC50 value of 5 nM and inhibits FcεRI-mediated rat RBL-2H3 basophil cell degranulation (EC50 = 1.4 μM).2 At 2 μM, this compound completely abolishes convulxin-induced platelet aggregation and shape change.3 |
| 别名 | OXSI 2;Spleen Tyrosine Kinase; |
性能| 供应商 | Cayman |
| 应用文献 |
1.Singh, R.,Masuda, E.S. and Payan, D.G. Discovery and development of spleen tyrosine kinase (SYK) inhibitors. Journal of Medicinal Chemistry 55(8), 3614-3643 (2012).
2.Lai, J.Y.Q.,Cox, P.J.,Patel, R., et al. Potent small molecule inhibitors of spleen tyrosine kinase (Syk). Bioorganic & Medicinal Chemistry Letters 13(18), 3111-3114 (2003).
3.Bhavaraju, K.,Kim, S.,Daniel, J.L., et al. Evaluation of [3-(1-methyl-1H-indol-3-yl-methylene)-2-oxo-2, 3-dihydro-1H-indole-5-sulfonamide] (OXSI-2), as a Syk selective inhibitor in platelets. European Journal of Pharmacology 580(3), 285-290 (2008).
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| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥95% (mixture of isomers) |
| 计算分子量 | 353.4 |
| 分子式 | C18H15N3O3S |
| CAS号 | 622387-85-3 |
| 稳定性 | ≥ 2 years |
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