KT195
货号：
14818-1mg 基本售价：
350.0 元 规格：
1 mg
产品信息
概述| 货号 | 14818-1mg |
| 描述 | The serine hydrolase known as α/β-hydrolase domain-containing protein 6 (ABHD6) hydrolyzes 2-arachidonoyl glycerol (2-AG; Item No. 62160) to regulate its availability at cannabinoid receptors. KT195 is a selective inhibitor of ABHD6 (IC50 = 10 nM) with negligible activity against other serine hydrolases such as DAGLβ.1,2 While it can be used as a probe to study ABHD6, it also has use as a negative control for studies of DAGLβ.1 By inactivating ABHD6, KT195 has been shown to induce a significant accumulation of 2-AG in Neuro2a cells.1 KT195 is also reported to reduce IL-1β secretion from lipopolysaccharide-treated macrophages.1 |
| 别名 | ML-295; |
性能| 供应商 | Cayman |
| 应用文献 |
1.Hsu, K.L.,Tsuboi, K.,Adibekian, A., et al. DAGLβ inhibition perturbs a lipid network involved in macrophage inflammatory responses. Nature Chemical Biology 8(12), 999-1007 (2012).
2.Iglesias, J.,Lamontagne, J.,Erb, J., et al. Simplified assays of lipolysis enzymes for drug discovery and specificity assessment of known inhibitors. Journal of Lipid Research 57(1), 131-141 (2016).
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| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥98% |
| 计算分子量 | 438.5 |
| 分子式 | C27H26N4O2 |
| CAS号 | 1402612-58-1 |
| 稳定性 | ≥ 2 years |
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