| 货号 | 14751-5mg |
| 描述 | Shikonin is a naturally occurring naphthoquinine isolated from the dried root of L. erythrorhizon, an herb used in traditional Chinese medicine. It increases glucose uptake by adipocytes and myocytes and inhibits the activity of phosphatase and tensin homolog (PTEN; IC50 = 2.7 µM).1,2 It inhibits glycolysis in cancer cells by inhibiting tumor-specific pyruvate kinase M2(IC50 = 0.3 µM).3 Shikonin induces cell death consistent with necroptosis in MCF-7 and HEK293 cancer cell lines.4 It inhibits leukocyte migration, downregulates chemokine receptor expression, and inhibits HIV-1 replication at nanomolar concentrations.5 Shikonin exhibits anti-inflammatory activity, reducing joint swelling and cartilage destruction in a mouse model of collagen-induced arthritis.6 |
| 别名 | C.I. 75535;Isoarnebin 4;NSC 252844; |
| 供应商 | Cayman |
| 应用文献 | |
| 1.Kamei, R.,Kitagawa, Y.,Kadokura, M., et al. Shikonin stimulates glucose uptake in 3T3-L1 adipocytes via an insulin-independent tyrosine kinase pathway. Biochemical and Biophysical Research Communications 292(3), 642-651 (2002). 2.Nigorikawa, K.,Yoshikawa, K.,Sasaki, T., et al. A naphthoquinone derivative, shikonin, has insulin-like actions by inhibiting both phosphatase and tensin homolog deleted on chromosome 10 and tyrosine phosphatases. Molecular Pharmacology 70(3), 1143-1149 (2006). 3.Chen, J.,Xie, J.,Jiang, Z., et al. Shikonin and its analogs inhibit cancer cell glycolysis by targeting tumor pyruvate kinase-M2. Oncogene 30(42), 4297-4306 (2011). 4.Han, W.,Li, L.,Qiu, S., et al. Shikonin circumvents cancer drug resistance by induction of a necroptotic death. Molecular Cancer Therapeutics 6(5), 1641-1649 (2007). 5.Chen, X.,Yang, L.,Zhang, N., et al. Shikonin, a component of chinese herbal medicine, inhibits chemokine receptor function and suppresses human immunodeficiency virus type 1. Antimicrobial Agents and Chemotherapy 47(9), 2810-2816 (2003). 6.Kim, Y.O.,Hong, S.J. and Yim, S.V. The efficacy of shikonin on cartilage protection in a mouse model of rheumatoid arthritis. Korean J.Physiol.Pharmacol. 14(4), 199-204 (2010). | |
| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥98% |
| 计算分子量 | 288.3 |
| 分子式 | C16H16O5 |
| CAS号 | 517-89-5 |
| 稳定性 | ≥ 2 years |
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