JFD00244
货号：
14648-1mg 基本售价：
350.0 元 规格：
1 mg
产品信息
概述| 货号 | 14648-1mg |
| 描述 | Human sirtuin 2 (SIRT2) is a NAD+-dependent protein deacetylase with diverse targets, including α-tubulin, phosphoenolpyruvate carboxykinase, and forkhead box protein O1. JFD00244 is an inhibitor of SIRT2 (IC50= 56.7 µM).1 At 5 µM, JFD00244 induces granulocytic differentiation in the acute promyelocytic leukemia cell line NB4.2 |
| 别名 | BML-266; |
性能| 供应商 | Cayman |
| 应用文献 |
1.Kiviranta, P.H.,Leppänen, J.,Kyrylenko, S., et al. N,N-Bisbenzylidenebenzene-1,4-diamines and N,N-bisbenzylidenenaphthalene-1,4-diamines as sirtuin type 2 (SIRT2) inhibitors. Journal of Medicinal Chemistry 49(26), 7907-7911 (2006).
2.Sunami, Y.,Araki, M.,Hironaka, Y., et al. Inhibition of the NAD-dependent protein deacetylase SIRT2 induces granulocytic differentiation in human leukemia cells. PLoS One 8(2), 57633 (2013).
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| 运输条件 | Wet ice in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥95% |
| 计算分子量 | 478.5 |
| 分子式 | C30H26N2O4 |
| CAS号 | 96969-83-4 |
| 稳定性 | ≥ 2 years |
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