| 货号 | 14636-5mg |
| 描述 | Platelet-activating factor (PAF) is an important mediator of cell proliferation, angiogenesis, inflammatory response regulation, vasodilation, superoxide formation, and platelet aggregation.1 These cellular effects are mediated through its specific G-protein coupled receptor, PAFR.2 Ginkgolide B, a terpenoid extracted from G. biloba leaves, is a potent PAFR antagonist that inhibits platelet aggregation at concentrations from 10-500 μM.3 It has been shown to inhibit non-mucinous ovarian cancer proliferation by blocking cell cycling.4 Ginkgolide B also demonstrates number of other anti-inflammatory, anti-allergic, antioxidant, and neuroprotective effects.5 |
| 别名 | BN 52021;BN 52051; |
| 供应商 | Cayman |
| 应用文献 | |
| 1.Prescott, S.M.,Zimmerman, G.A. and McIntyre, T.M. Platelet-activating factor. The Journal of Biological Chemisty 265, 17381-17384 (1990). 2.Funkunaga, K.,Ishii, S.,Asano, K., et al. Single nucleotide polymorphism of human platelet-activating factor impairs G-protein activation. The Journal of Biological Chemisty 276(46), 43025-43030 (2001). 3.Cho, H.J. and Nam, K.S. Inhibitory effect of ginkgolide B on platelet aggregation in a cAMP- and cGMP-dependent manner by activated MMP-9. Journal of Biochemistry and Molecular Biology 40(5), 678-683 (2007). 4.Aponte, M.,Jiang, W.,Lakkis, M., et al. Activation of PAF-receptor and pleiotropic effects on tyrosine phospho-EGFR/Src/FAK/paxillin in ovarian cancer. Cancer Research 68(14), 5839-5848 (2008). 5.Shi-hai, X. and Dian-chun, F. Pharmacological action and mechanisms of ginkgolide B. Chinese Medical Journal 120(10), 922-928 (2007). | |
| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥98% |
| 计算分子量 | 424.4 |
| 分子式 | C20H24O10 |
| CAS号 | 15291-77-7 |
| 稳定性 | ≥ 2 years |
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