| 货号 | 14611-1mg |
| 描述 | AY 9944 prevents cholesterol biosynthesis by inhibiting the 7-dehydro cholesterol Δ7-reductase (DHCR7) enzyme (IC50 = 13 nM), which interferes with the conversion of 7-dehydro cholesterol (Item No. 14612) to cholesterol.1,2 Furthermore, by upregulating the expression of DHCR7, AY 9944 can block Hedgehog signaling at the level of Smoothened or by loss of Suppressor of Fused.3 AY 9944 inhibition of DHCR7 has been used to recapitulate phenotypes of Smith-Lemli-Opitz syndrome, a disorder brought about by mutations in the DHCR7 gene, in animal models.2,4 However, AY 9944 is highly teratogenic, producing congenital defects in offspring when fed to pregnant animals.5 |
| 供应商 | Cayman |
| 应用文献 | |
| 1.Horlick, L. Effect of a new inhibitor of cholesterol biosynthesis (AY 9944) on serum and tissue sterols in the rat. Journal of Lipid Research 7(1), 116-121 (1966). 2.Moebius, F.F.,Fitzky, B.U.,Lee, J.N., et al. Molecular cloning and expression of the human δ7-sterol reductase. Proceedings of the National Academy of Sciences of the United States of America 95(4), 1899-1902 (1998). 3.Lauth, M.,Rohnalter, V.,Bergström, A., et al. Antipsychotic drugs regulate hedgehog signaling by modulation of 7-dehydrocholesterol reductase levels. Molecular Pharmacology 78(3), 486-496 (2010). 4.Keller, R.K.,Mitchell, D.A.,Goulah, C.C., et al. Hepatic isoprenoid metabolism in a rat model of Smith-Lemli-Opitz Syndrome. Lipids 48(3), 219-229 (2013). 5.Xu, G.,Salen, G.,Shefer, S., et al. Reproducing abnormal cholesterol biosynthesis as seen in the Smith-Lemli-Opitz syndrome by inhibiting the conversion of 7-dehydrocholesterol to cholesterol in rats. Journal of Clinical Investigation 95(1), 76-81 (1995). | |
| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥98% |
| 计算分子量 | 464.3 |
| 分子式 | C22H28Cl2N2 • 2HCl |
| CAS号 | 366-93-8 |
| 稳定性 | ≥ 2 years |
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