| 货号 | 14575-5mg |
| 描述 | 1-EBIO is an activator of Ca2+-sensitive K+ channels (EC50 = 490 µM in T84 human carcinoma cells).1 This action is sensitive to the neurotoxin charybdotoxin (Ki = 3.5 nM). In mouse colonic epithelia, 1-EBIO also activates cAMP-sensitive K+ channels, a response this is inhibited by 293B.2 In this type of epithelium, but not mouse nasal epithelia, 1-EBIO activates both types of channels, resulting in large Cl- secretory currents.3 It also activates the human intermediate conductance Ca2+-activated K+ channel (EC50 = 74 µM).4 1-EBIO is currently used to study the role of these types of K+ channels in diverse physiological functions.5,6 |
| 别名 | 1-Ethylbenzimidazolinone; |
| 供应商 | Cayman |
| 应用文献 | |
| 1.Devor, D.C.,Singh, A.K.,Frizzell, R.A., et al. Modulation of Cl- secretion by benzimidazolones. I. Direct activation of a Ca(2+)-dependent K+ channel. American Journal of Physiology 271, L775-L784 (1996). 2.Cuthbert, A.W.,Hickman, M.E.,Thorn, P., et al. Activation of Ca2+- and cAMP-sensitive K+ channels in murine colonic epithelia by 1-ethyl-2-benzimidazolone. American Journal of Physiology.Endocrinology and Metabolism 277(1), C111-C120 (1999). 3.MacVinish, L.J.,Hickman, M.E.,Mufti, D.A., et al. Importance of basolateral K+ conductance in maintaining Cl- secretion in murine nasal and colonic epithelia. Journal of Physiology 510(1), 237-247 (1998). 4.Jensen, B.S.,Strobæk, D.,Christophersen, P., et al. Characterization of the cloned human intermediate-conductance Ca2+-activated K+ channel. American Journal of Physiology 275(3), C848-C856 (1998). 5.Gao, Z.,Todorov, B.,Barrett, C.F., et al. Cerebellar ataxia by enhanced Cav2.1 currents is alleviated by Ca+2-dependent K+-channel activators in CacnalaS218L mutant mice. Journal of Neuroscience 32(44), 15533-15546 (2012). 6.Maiz, J.,Karakossian, M.H.,Pakaprot, N., et al. Prolonging the postcomplex spike pause speeds eyeblink conditioning. Proceedings of the National Academy of Sciences of the United States of America 109(41), 16726-16730 (2012). | |
| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥98% |
| 计算分子量 | 162.2 |
| 分子式 | C9H10N2O |
| CAS号 | 10045-45-1 |
| 稳定性 | ≥ 2 years |
| 本官网所有报价均为常温或者蓝冰运输价格，如有产品需要干冰运输，需另外加收干冰运输费。 |