(+)-Pilocarpine (hydrochloride)
货号：
14487-500mg 基本售价：
350.0 元 规格：
500 mg
产品信息
概述| 货号 | 14487-500mg |
| 描述 | (+)-Pilocarpine is a muscarinic M1 and M2 acetylcholine receptor agonist with pKB values of 5 and 3.7, respectively.1 Systemic administration of (+)-pilocarpine is typically used as an animal model for temporal lobe epilepsy and can mimic the generation of complex partial seizures by producing changes in hippocampal neuron morphology, membrane properties, and synaptic responses.2 |
| 别名 | NSC 5746;Isopto Carpine;Salagen;Sanpilo; |
性能| 供应商 | Cayman |
| 应用文献 |
1.Thomas, R.L.,Langmead, C.J.,Wood, M.D., et al. Contrasting effects of allosteric and orthosteric agonists on M1 muscarinic acetylcholine receptor internalization and down-regulation. Journal of Pharmacology and Experimental Therapeutics 331(3), 1086-1095 (2009).
2.Smolders, I.,Khan, G.M.,Manil, H., et al. A receptor-mediated pilocarpine-induced seizures: Characterization in freely moving rats by microdialysis. British Journal of Pharmacology 121(6), 1171-1179 (1997).
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| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥98% |
| 计算分子量 | 244.7 |
| 分子式 | C11H16N2O2 • HCl |
| CAS号 | 54-71-7 |
| 稳定性 | ≥ 2 years |
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