| 货号 | 14486-1g |
| 描述 | Carbamoylcholine, also known as carbachol, is an analog of acetylcholine that activates acetylcholine receptors (AChR). Carbamoylcholine is an agonist of both nicotinic (nAChR) and muscarinic (mAChR) receptors, with reported Ki values ranging from 10 to 10,000 nM for different receptors and different preparations.1,2,3,4,5 Carbamoylcholine (chloride) is used to study responses mediated by nAChR and mAChR, including smooth muscle contraction, gut motility, and neuronal signaling.6,7,8 |
| 别名 | Carbachol; |
| 是否危险品 | 是 |
| 供应商 | Cayman |
| 应用文献 | |
| 1.Dávila-García, M.I.,Musachio, J.L.,Perry, D.C., et al. [125I]IPH, an epibatidine analog, binds with high affinity to neuronal nicotinic cholinergic receptors. Journal of Pharmacology and Experimental Therapeutics 282(1), 445-451 (1997). 2.Eaton, J.B.,Peng, J.H.,Schroeder, K.M., et al. Characterization of human α4β 2-nicotinic acetylcholine receptors stably and heterologously expressed in native nicotinic receptor-null SH-EP1 human epithelial cells. Molecular Pharmacology 64(6), 1283-1294 (2003). 3.Grinevich, V.P.,Letchworth, S.R.,Lindenberger, K.A., et al. Heterologous expression of human α6β4β3α5 nicotinic acetylcholine receptors: Binding properties consistent with their natural expression require quaternary subunit assembly including the α5 subunit. J. Pharm. Exp. Ther. 312(2), 619-626 (2005). 4.Jensen, A.A.,Mikkelsen, I.,Frolund, B., et al. Carbamoylcholine homologs: Novel and potent agonists at neuronal nicotinic acetylcholine receptors. Molecular Pharmacology 64(4), 865-875 (2003). 5.Xiao, Y. and Kellar, K.J. The comparative pharmacology and up-regulation of rat neuronal nicotinic receptor subtype binding sites stably expressed in transfected mammalian cells. Journal of Pharmacology and Experimental Therapeutics 310(1), 98-107 (2004). 6.Aldini, R.,Micucci, M.,Cevenini, M., et al. Antiinflammatory effect of phytosterols in experimental murine colitis model: Prevention, induction, remission study. PLoS One 9(9), 1-16 (2014). 7.Lee, H.S.,Ghetti, A.,Pinto-Duarte, A., et al. Astrocytes contribute to gamma oscillations and recognition memory. Proc.Nat.Acad.Sci.USA 111(32), E3343-E3352 (2014). 8.Mori, D.,Watanabe, N.,Kaminuma, O., et al. IL-17A induces hypo-contraction of intestinal smooth muscle via induction of iNOS in muscularis macrophages. Journal of Pharmacological Sciences 125(4), 394-405 (2014). | |
| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥98% |
| 计算分子量 | 182.7 |
| 分子式 | C6H15N2O2 • Cl |
| CAS号 | 51-83-2 |
| 稳定性 | ≥ 2 years |
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