Ac-DEVD-pNA
货号：
14460-1mg 基本售价：
350.0 元 规格：
1 mg
产品信息
概述| 货号 | 14460-1mg |
| 描述 | During apoptosis, activated caspase-3 cleaves several substrates, including poly(ADP-ribose) polymerase, which it specifically targets at the amino sequence DEVD.1 Ac-DEVD-pNA is a para-nitro aniline chromophore cleaved by caspases (Km = 18, 11, 32, 180, and 12 µM for caspases-1, -3, -4, -6, and -7, respectively).2 It is not cleaved by caspase-2.2 Cleavage is monitored colorimetrically at 405 nm. |
| 别名 | N-Acetyl-Asp-Glu-Val-Asp-p-Nitroanilide; |
性能| 供应商 | Cayman |
| 应用文献 |
1.Lazebnik, Y.A.,Kaufmann, S.H.,Desnoyers, S., et al. Cleavage of poly(ADP-ribose) polymerase by a proteinase with properties like ICE. Nature 371, 346-347 (1994).
2.Talanian, R.V.,Quinlan, C.,Trautz, S., et al. Substrate specificities of caspase family proteases. The Journal of Biological Chemisty 272, 9677-9682 (1997).
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| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥95% |
| 计算分子量 | 638.6 |
| 分子式 | C26H34N6O13 |
| CAS号 | 189950-66-1 |
| 稳定性 | ≥ 2 years |
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