Teniposide
货号：
14425-10mg 基本售价：
350.0 元 规格：
10 mg
产品信息
概述| 货号 | 14425-10mg |
| 描述 | Teniposide is a podophyllotoxin derivative that causes dose-dependent single- and double-stranded breaks in DNA by inhibiting topoisomerase II. Its cytostatic effects are related to its ability to stabilize the DNA-topoisomerase II complex during DNA replication, inducing DNA damage and cellular apoptosis.1 Teniposide has been widely used in the treatment of various cancers including, small cell lung cancer, malignant lymphoma, breast cancer, oral squamous cell carcinoma, and acute lymphoblastic leukemia.2 |
| 别名 | NSC 122819;VM-26; |
性能| 供应商 | Cayman |
| 应用文献 |
1.Richter, A.,Strausfeld, U. and Knippers, R. Effects of VM26 (teniposide), a specific inhibitor of type II DNA topoisomerase, on SV40 DNA replication in vivo. Nucleic Acids Research 15(8), 3455-3468 (1987).
2.Li, J.,Chen, W.,Zhang, P., et al. Topoisomerase II trapping agent teniposide induces apoptosis and G2/M or S phase arrest of oral squamous cell carcinoma. World J.Surg.Oncol. 4(1), 41 (2006).
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| 运输条件 | Wet ice in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥98% |
| 计算分子量 | 656.7 |
| 分子式 | C32H32O13S |
| CAS号 | 29767-20-2 |
| 稳定性 | ≥ 2 years |
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