LE 135
货号：
14415-1mg 基本售价：
350.0 元 规格：
1 mg
产品信息
概述| 货号 | 14415-1mg |
| 描述 | LE 135 is a retinoic acid receptor (RAR) antagonist that displays moderate selectivity for RARβ over RARα (Kis = 0.22 and 1.4 μM, respectively).1,2 LE 135 inhibits retinoic acid-induced transcriptional activation of RARβ (>70% inhibition at 10 μM), but not RARα, RARγ or retinoid X receptor α.1 It has been shown to inhibit retinoid Am80-induced differentiation of human promyelocytic leukemia cells, HL-60, with an IC50 value of 0.2 μM.3 |
性能| 供应商 | Cayman |
| 应用文献 |
1.Li, Y.,Hashimoto, Y.,Agadir, A., et al. Identification of a novel class of retinoic acid receptor ß-selective retinoid antagonists and their inhibitory effects on AP-1 activity and retinoic acid-induced apoptosis in human breast cancer cells. J.Bio.Chem. 274 (22), 15360-15366 (1999).
2.Eyrolles, L.,Kagechika, H.,Kawachi, E., et al. Retinobenzoic Acids. 6. Retinoid antagonists with a heterocyclic ring. Journal of Medicinal Chemistry 37, 1508-1517 (1994).
3.Umemiya, H.,Fukasawa, H.,Ebisawa, M., et al. Regulation of retinoidal actions by diazepinylbenzoic acids. Retinoid synergists which activate the RXR-RAR heterodimers. Journal of Medicinal Chemistry 40(26), 4222-4234 (1997).
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| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥98% |
| 计算分子量 | 438.6 |
| 分子式 | C29H30N2O2 |
| CAS号 | 155877-83-1 |
| 稳定性 | ≥ 2 years |
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