SIRT1/2 Inhibitor IV
货号：
14407-1mg 基本售价：
350.0 元 规格：
1 mg
产品信息
概述| 货号 | 14407-1mg |
| 描述 | SIRT1/2 inhibitor IV is a cell-permeable inhibitor of SIRT1 (IC50 = 56 µM) and SIRT2 (IC50 = 59 µM), blocking NAD+-dependent deacetylase activity in a substrate competitive manner.1 It less effectively inhibits SIRT5 (IC50 >300 µM) and has no effect on class I and II histone deacetylases.1 By inhibiting SIRT1, SIRT1/2 inhibitor IV sensitizes H460 lung cancer cells to etoposide and paclitaxel and enhances etoposide-induced G2arrest.1 It also blocks a SIRT1-dependent hypoxic response in vivo, suppressing HIF-1α protein accumulation as well as EPO and VEGF expression in HepG2 tumors in mice.2 |
| 别名 | Cambinol;NSC 112546;SIRT1 Inhibitor II;SIRT2 Inhibitor VI; |
性能| 供应商 | Cayman |
| 应用文献 |
1.Heltweg, B.,Gatbonton, T.,Schuler, A.D., et al. Antitumor activity of a small-molecule inhibitor of human silent information regulator 2 enzymes. Cancer Research 66, 4368-4377 (2006).
2.Laemmle, A.,Lechleiter, A.,Roh, V., et al. Inhibition of SIRT1 impairs the accumulation and transcriptional activity of HIF-1α protein under hypoxic conditions. PLoS One 7(3), (2012).
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| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥98% |
| 计算分子量 | 360.4 |
| 分子式 | C21H16N2O2S |
| CAS号 | 14513-15-6 |
| 稳定性 | ≥ 2 years |
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