| 货号 | 14317-10mg |
| 描述 | (S)-Duloxetine is a potent inhibitor of serotonin and norepinephrine reuptake (Kis = 4.6 and 15.6 nM, respectively, for rat synaptosomes).1 It less effectively inhibits dopamine reuptake (Ki = 369 nM).1 It is effective in cells, tissues, and in vivo.1,2 (S)-Duloxetine has applications in many chronic medical conditions, including major depressive disorder, generalized anxiety disorder, chronic neuropathic and musculoskeletal pain, and fibromyalgia.3,4 |
| 别名 | Cymbalta;Dulane 20;LY248686; |
| 供应商 | Cayman |
| 应用文献 | |
| 1.Wong, D.T.,Bymaster, F.P.,Mayle, D.A., et al. LY248686, a new inhibitor of serotonin and norepinephrine uptake. Neuropsychopharmacology 8(1), 23-33 (1993). 2.Kasamo, K.,Blier, P. and De Montigny, C. Blockade of the serotonin and norepinephrine uptake processes by duloxetine: In vitro and in vivo studies in the rat brain. Journal of Pharmacology and Experimental Therapeutics 277(1), 278-286 (1996). 3.Able, S.L.,Cui, Z. and Shen, W. Duloxetine treatment adherence across mental health and chronic pain conditions. Clinicoecon Outcomes Res. 6, 75-81 (2014). 4.Ball, S.G.,Desaiah, D.,Zhang, Q., et al. Efficacy and safety of duloxetine 60 mg once daily in major depressive disorder: A review with expert commentary. Drugs Context 2013, (2013). | |
| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥98% |
| 计算分子量 | 333.9 |
| 分子式 | C18H19NOS • HCl |
| CAS号 | 136434-34-9 |
| 稳定性 | ≥ 2 years |
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