Plumbagin
货号：
14314-100mg 基本售价：
350.0 元 规格：
100 mg
产品信息
概述| 货号 | 14314-100mg |
| 描述 | Plumbagin is a natural 1,4-naphthoquinone first isolated from plants of the genus Plumbago. It has diverse effects in cells and animals. Plumbagin causes the generation of reactive oxygen species and induces apoptosis in cancer cells.1,2 It activates signaling through Nrf2 and the antioxidant response element, inducing the expression of Nrf2 target genes, including NQO1 and heme oxygenase-1 in cultured neuronal cells.1 Plumbagin also inhibits NADPH oxidase 4 in a time- and dose-dependent manner.3 It can be protective against peroxide stress or deprivation of glucose or oxygen.1 |
| 别名 | NSC 236613;NSC 688284; |
性能| 供应商 | Cayman |
| 应用文献 |
1.Klotz, L.O.,Hou, X. and Jacob, C. 1,4-Naphthoquinones: From oxidative damage to cellular and inter-cellular signaling. Molecules 19(9), 14902-14918 (2014).
2.Gupta, S.C.,Kim, J.H.,Prasad, S., et al. Regulation of survival, proliferation, invasion, angiogenesis, and metastasis of tumor cells through modulation of inflammatory pathways by nutraceuticals. Cancer Metastasis Reviews 29(3), 405-434 (2010).
3.Schramm, A.,Matusik, P.,Osmenda, G., et al. Targeting NADPH oxidases in vascular pharmacology. Vascular Pharmacology 56(5-6), 216-231 (2012).
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| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥98% |
| 计算分子量 | 188.2 |
| 分子式 | C11H8O3 |
| CAS号 | 481-42-5 |
| 稳定性 | ≥ 2 years |
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