ANA-12
货号：
14309-1mg 基本售价：
350.0 元 规格：
1 mg
产品信息
概述| 货号 | 14309-1mg |
| 描述 | ANA-12 is a TrkB receptor antagonist that prevents activation of the receptor by BDNF with IC50 values of 45.6 nM and 41.1 μM for the high and low affinity sites of the receptor, respectively.1 It does not affect TrkA or TrkC in an assay of neurite outgrowth.1 Mice administered ANA-12 demonstrated reduced anxiety- and depression-related behaviors on a variety of tests predictive of anxiolytic and antidepressant properties in humans.1 |
性能| 供应商 | Cayman |
| 应用文献 |
1.Cazorla, M.,Prémont, J.,Mann, A., et al. Identification of a low-molecular weight TrkB antagonist with anxiolytic and antidepressant activity in mice. J.Clin.Invest. 121(5), 1846-1857 (2011).
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| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥98% |
| 计算分子量 | 407.5 |
| 分子式 | C22H21N3O3S |
| CAS号 | 219766-25-3 |
| 稳定性 | ≥ 2 years |
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