| 货号 | 14283-5mg |
| 描述 | The calpains are a family of calcium-dependent cysteine proteases that catalyze limited proteolysis of substrates.1 Calpain Inhibitor III is a cell permeable, selective inhibitor of μ-calpain (calpain-1) and m-calpain (calpain-2).2 Calpain Inhibitor III crosses the blood-brain barrier to inhibit brain cysteine protease activity and has been reported to have neuroprotective effects in numerous rodent neurotrauma models, including spinal cord injury, cortical impact trauma, neonatal hypoxia-ischemia, and focal cerebral ischemia.3 Additionally, Calpain Inhibitor III has been shown to attenuate depression in myocardial contractile performance that occurs during reperfusion following cardiac ischemia.4 |
| 别名 | MDL 28170; |
| 供应商 | Cayman |
| 应用文献 | |
| 1.Mellgren, R.L. Specificities of cell permeant peptidyl inhibitors for the proteinase activities of μ-calpain and the 20 S proteasome. The Journal of Biological Chemisty 272(47), 29899-29903 (1997). 2.Mehdi, S. Cell-penetrating inhibitors of calpain. Trends in Biochemical Sciences 16(4), 150-153 (1991). 3.Thompson, S.N.,Carrico, K.M.,Mustafa, A.G., et al. A pharmacological analysis of the neuroprotective efficacy of the brain- and cell-permeable calpain inhibitor MDL-28170 in the mouse controlled cortical impact traumatic brain injury model. J.Neurotrauma 27, 2233-2243 (2010). 4.Urthaler, F.,Wolkowicz, P.E.,Digerness, S.B., et al. MDL-28170, a membrane-permeant calpain inhibitor, attenuates stunning and PKC proteolysis in reperfused ferret hearts. Cardiovascular Research 35(1), 60-67 (1997). | |
| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥95% |
| 计算分子量 | 382.5 |
| 分子式 | C22H26N2O4 |
| CAS号 | 88191-84-8 |
| 稳定性 | ≥ 2 years |
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