| 货号 | 14253-1mg |
| 描述 | Luotonin A is an alkaloid originally isolated from a plant used in traditional Chinese medicine.1 It inhibits the growth of mouse leukemia P388 cells (IC50 = 1.8 μg/ml).1 Luotonin A is structurally similar to the alkaloid camptothecin (Item No. 11694) and, like camptothecin, it binds to and stabilizes the topoisomerase I-DNA binary complex, leading to DNA breakage and cell death (IC50 = 5.07-12.6 μM).2 Also like camptothecin, luotonin A forms non-covalent complexes with double-stranded DNA in the minor groove and this association can be followed by native fluorescence associated with the aromatic and heterocyclic ring structure.3 Luotonin A also selectively inhibits the cytochrome P450 (CYP) isoforms CYP1A1 and CYP1A2 (IC50 = ~6 μM for each) in human liver microsomes.4 |
| 供应商 | Cayman |
| 应用文献 | |
| 1.Liang, J.L.,Cha, H.C. and Jahng, Y. Recent advances in the studies on luotonins. Molecules 16(6), 4861-4883 (2011). 2.Cagir, A.,Jones, S.H.,Gao, R., et al. Luotonin A. A naturally occurring human DNA topoisomerase I poison. Journal of the American Chemical Society 125(45), 13628-13629 (2003). 3.Mussardo, P.,Corda, E.,González-Ruiz, V., et al. Study of non-covalent interactions of luotonin A derivatives and the DNA minor groove as a first step in the study of their analytical potential as DNA probes. Analytical and Bioanalytical Chemistry 400(2), 321-327 (2011). 4.Jahng, Y.,Kwon, O.K. and Lee, S. In vitro inhibitory effect of luotonin A on human CYP1A. Archives of Pharmacal Research 35(12), 2199-2203 (2012). | |
| 运输条件 | Wet ice in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥98% |
| 计算分子量 | 285.3 |
| 分子式 | C18H11N3O |
| CAS号 | 205989-12-4 |
| 稳定性 | ≥ 2 years |
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