| 货号 | 14250-50mg |
| 描述 | Bicalutamide is a non-steroidal androgen receptor antagonist that binds the androgen receptor (Ki = 12.5 μM; IC50 = 1.2 μM), preventing its activation and subsequent upregulation of androgen responsive genes by androgenic hormones.1,2 Bicalutamide is frequently used to examine the role of androgen receptor inactivation in the proliferation of prostate cancer cells and has served as a molecular template for the design and structural optimization of more selective androgen receptor modulators for androgen therapy.3,4 |
| 别名 | ICI 176334;ZD 176334; |
| 供应商 | Cayman |
| 应用文献 | |
| 1.Freeman, S.N.,Mainwaring, W.I.P. and Furr, B.J.A. A possible explanation for the peripheral selectivity of a novel non-steroidal pure antiandrogen, Casodex (ICI 176,334). Br. J. Cancer 60(5), 664-668 (1989). 2.Masiello, D.,Cheng, S.,Bubley, G.J., et al. Bicalutamide functions as an androgen receptor antagonist by assembly of a transcriptionally inactive receptor. The Journal of Biological Chemisty 277(29), 26321-26326 (2002). 3.Gao, W.,Kim, J. and Dalton, J.T. Pharmacokinetics and pharmacodynamics of nonsteroidal androgen receptor ligands. Pharmaceutical Research 23(8), 1641-1658 (2006). 4.Yin, D.,Perera, M.A.,Dalton, J.T., et al. Key structural features of nonsteroidal ligands for binding and activation of the androgen receptor. Molecular Pharmacology 63(1), 211-223 (2003). | |
| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥98% |
| 计算分子量 | 430.4 |
| 分子式 | C18H14F4N2O4S |
| CAS号 | 90357-06-5 |
| 稳定性 | ≥ 2 years |
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